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The absence of pharmacokinetic or pharmacodynamic interaction studies means healthcare providers must rely on theoretical considerations and the known pharmacology of each component when patients inquire about combination use

Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, Rudnick DA

A broad range of nutritional interventions is possible, so a pragmatic model that rationalises their indications and use may be helpful in clinical practice (Figure 2)

In the clinic, we find that for immediate relief, magnesium citrate, magnesium oxide, or milk of magnesia can work within hours, while senna or aloe vera offer overnight results