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Description

POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

NADP + as a ligand was extracted from E

A few biomarkers had stronger associations, such as: endocrine-disrupting chemicals (ORs 4.1, -3.3, and -3.2), some phthalates (ORs 0.44, 0.41, and 0.49), polyunsaturated fats (s 0.009 and 0.11), using air conditioning (OR 0.32), indoor pesticide exposure in low folate intake women (OR 2.5), having 6 dental amalgams (OR 3.2), maternal fish and fruit consumption (OR 0.28 and 0.41, respectively), having newborn complications (OR 4.7), occupational exposures (OR 2.3), and maternal depression (OR 4.82)