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Although early-phase studies in healthy volunteers suggested an acceptable safety profile for ARC-520, the overall program was terminated after lethal toxicity of the EX1 dynamic polyconjugate delivery vehicle was observed in non-human primates, highlighting how delivery-related toxicities can block TRL progression even when on-target antiviral effects are demonstrated

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Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells