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Regarding weight loss and insulin sensitivity, one study found that overweight and obese women who had a daily dose of green tea tablets showed a significant drop in body weight as well as an improvement in insulin sensitivity compared to the placebo group [169]
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doi: 10.1134/S0006297920080052 28 KalyanaramanBChengGHardyMYouM

So, for example, 8M urea or 6M guanidine HCl would likely denature GST, preventing the GST-glutathione interaction that serves as the foundation for this purification
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