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Published rodent serum half-life estimates cluster in the range of minutes to a few hours short, by the standards of therapeutic peptides

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The basic characteristics of PCOS patients and controls are listed in Supplementary Data 1

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Similarly, despite the reported tolerability and indication of efficacy of the MCHR1 antagonist ALB-127158, its development was terminated before the initiation of Phase II studies

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Zou Y, Sun X, Wang Y, Yan C, Liu Y, Li J, et al

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The rationale for titrating upward over time, rather than starting at the target dose, mirrors the approach taken with other metabolic peptides: the goal is to identify the minimum effective dose for each individual while monitoring for tolerability

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