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Published rodent serum half-life estimates cluster in the range of minutes to a few hours short, by the standards of therapeutic peptides

The basic characteristics of PCOS patients and controls are listed in Supplementary Data 1

Similarly, despite the reported tolerability and indication of efficacy of the MCHR1 antagonist ALB-127158, its development was terminated before the initiation of Phase II studies

Zou Y, Sun X, Wang Y, Yan C, Liu Y, Li J, et al

The rationale for titrating upward over time, rather than starting at the target dose, mirrors the approach taken with other metabolic peptides: the goal is to identify the minimum effective dose for each individual while monitoring for tolerability