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The majority of the brain ApoE (7580%) is derived from astrocytes, with 1520% in neurons and lesser contributions from oligodendrocytes, endothelial cells and microglia (Blumenfeld et al., 2024)

In addition, adjunctive treatment with antioxidants such as vitamin E, red rice bran oil, and curcumin in the early phases of illness may prevent additional oxidative injury, and thus improve and prevent further possible worsening of related neurological and behavioral deficits in schizophrenia

Currently, transgenic mouse models overexpressing A53T and A30P mutations are extensively utilized

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