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c , Dose-dependent rescue of three independent COQ2 -knockout HT1080 cell clones (56, 61 and 68) by supplementation of the cell culture medium with uridine, CoQ 10 or decyl-ubiquinone

How viability can be attenuated and apoptosis induced without cytotoxicity can be explained based on the length of time that it takes a compound to induce apoptosis

The binding affinity between 5-R isoenzyme and 4-azasteroids can be described in the two step mechanism: Where i is the inhibition constant for the first step equilibrium and 3 is the rate constant for the time-dependent second step [92]

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