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Others have identified astrocytes as a target for the neuroprotective effects of UA, demonstrating effects on astrocytic glutathione and Nrf2, and providing further support for the involvement of UA in antioxidative processes 52

Preclinical Studies of N-Acetylcysteine for Treatment of Traumatic Brain Injury NAC emerged as a potential therapy for TBI in the 1990s with a report using an experimental model of fluid percussion injury (FPI) in cats showing that NAC treatment improved cerebrovascular responsivity [12]

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For AAO1 and AAO2, a function in one of the multiple biosynthesis routes of indole-3-acetic acid is suggested as they both efficiently catalyze the oxidation of indole acetaldehyde to indole-3-acetic acid in vitro

Ito T, Kato M, Tsuchida H, Harada E et al (2011) Ergothioneine as an anti-oxidative/anti-inflammatory component in several edible mushrooms