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Indeed, the control of malaria has come a long way since then (though the ongoing covid-19 pandemic has unfortunately set progress back significantly [4])

Additionally, oxidative stress significantly impairs RFC function: Low glutathione: Reduces RFC function ~20-40% High nitric oxide: Reduces RFC function ~35% Hyperglycemia: Reduces RFC function ~20-35% Even if you're taking Leucovorin, oxidative stress can prevent it from reaching your brain

Amyotrophic lateral sclerosis: a clinical review

This could be because the Vitamin B12 is helping to regulate your cells and their metabolic cycles, and it could be because you use more energy during the day, thus napping less and finding your body ready for sleep at night