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These non-specific symptoms have led the condition to be underdiagnosed and mistaken for other conditions

In contrast, the same glargine administration program failed to improve these metabolic abnormalities in Atm -KO mice, indicating that ATM is crucial for insulins systemic metabolic effect and the loss of ATM leads to these metabolic abnormalities

A third protein in this complex is the cullin 3 (CUL3) ubiquitin ligase, which directs this degradation

doi: 10.1111/j.1600-079X.1999.tb00611.x 85 ZhangHSquadritoGLUppuRPryorWA

Pyroptosis-related DEGs were obtained by intersecting the DEGs identified from the four datasets with pyroptosis-related genes