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Medial prefrontal cortex glutamate is reduced in schizophrenia and moderated by measurement quality: a meta-analysis of proton magnetic resonance spectroscopy studies

It sits at the centre of the comparison between GLP-1 agonists, dual GLP-1/GIP agonists, and newer triple agonist approaches

doi: 10.1038/415977a 19 AsatiA.PichhodeM.NikhilK

True irritation requiring product discontinuation presents as persistent burning or stinging lasting beyond application period, significant redness spreading beyond application zone or lasting multiple hours, swelling of eyelids or periorbital area, increased sensitivity making area uncomfortable to touch, or itching suggesting allergic response
