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During oogenesis, DZN exposure leads to the production of poor-quality oocytes, a major cause of infertility, low pregnancy rates, and high abortion rates [16]

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Although the pKa value of Cys-thiol GSH is relatively high (8.99.4) [3], indicating low reactivity in the intracellular environment, its central role in protecting cells from reactive oxygen/nitrogen species (RONS) is based on enzyme-catalyzed reactions, efficient recycling pathways, as well as the mass effect achieved by its high intracellular concentrations (210 mM)