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Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline

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This duality in p53 function with ROS intensity may decide the cell fate, with the protective arm of p53 activating processes to reduce cell stress with lower ROS intensity, while higher ROS intensity tips the balance towards cell death