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Most peptides are degraded in the GI tract before they can exert biological effects, but KPVs small size (three amino acids) and PepT1 affinity allow it to reach intestinal tissue intact

Mechanisms of endogenous neuroprotective effects of astrocytes in brain injury

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Whilst this significantly reduces food intake and promotes weight loss, it also substantially limits the volume of nutrient-dense food a person can consume at any one time