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Studies of MPTP-induced and 6-OHDA-induced murine models of PD show greater striatal DA depletion in mice fed a high-fat diet compared to chow-fed animals

PMID 17084999
[PubMed] [Google Scholar] 72.Lasram M.M., Dhouib I.B., Annabi A., El Fazaa S., Gharbi N

Nair S, Huynh JP, Lampropoulou V, Loginicheva E, Esaulova E, Gounder AP, Boon ACM, Schwarzkopf EA, Bradstreet TR, Edelson BT, et al

Recent work has also described a pattern of cerebral glucose hypometabolism in iRBD associated with conversion to PD 29,30 , with occipital hypometabolism a key feature, although this application of FDG-PET requires further validation
