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These drugs exert significant cochleotoxic effects through multiple biochemical pathways

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Nishikawa, M., Tamada, A., Kumai, H., Yamashita, F

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Experimental study demonstrates that LDN induces a phenotypic shift in BV-2 microglial cells, transitioning them from a pro-inflammatory(iNOS high CD206 low ) to a quiescent, anti-inflammatory M2 state (iNOS low CD206 high ) [150]