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It can take a few weeks to a month to notice the effects of B12 shots, since your body has to replenish your stores of this vitamin

Twice-daily dosing (500mcg morning and evening) shows up in more aggressive protocols but adds cost and injection logistics on top of an already-active TRT schedule

Folate Deficiency Affects Dendritic Cell Function and Subsequent T Helper Cell Differentiation

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Supplement with B12 at recommended doses, dont take more than you need, and dont be alarmed by studies linking high blood B12 to disease