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52 GlserK.KanawatiB.KuboT.Schmitt-KopplinP.GrillE

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Several studies have shown that DNA hypermethylation in cancer cells targets tumor suppressor genes explicitly, resulting in growth selection and uncontrolled cell proliferation [25,26,27,28]

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The diagnosis is ultimately clinical, supported by laboratory findings rather than defined solely by numerical thresholds

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Importantly, the Fenton reaction based on the release of Mn ions and the inactivation of GPX4 accompanied by accumulation of lipid peroxidation and ROS that can further sensitize Cuproptosis [173,174,175]

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