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doi: 10.1016/j.drup.2024.101059 60 QiRBaiYLiKLiuNXuYDalEet al
(2014) Altered glutamate cysteine ligase expression and activity in renal cell carcinoma, Biomed
Moreover, lutein can act as a pro-oxidant under tumor conditions: in gastric cancer cells, lutein elevated intracellular ROS via NADPH oxidase, which unexpectedly led to NF-Bmediated upregulation of pro-apoptotic factors and caspase-3 activation, culminating in apoptosis (46)
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