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[DOI] [PubMed] [Google Scholar] Kauffman K.J., Dorkin J.R., Yang J.H., Heartlein M.W., DeRosa F., Mir F.F., Fenton O.S., Anderson D.G

+ cluster in aconitase ( The excess accumulation of labile iron in the mitochondria of FRDA patients can react with the mitochondrial reactive oxygen species (ROS) that is inevitably present in these organelles due to occasional leakages of electron(s) from the electron transport chain (Zhao et al., 2019)

Under physiological conditions, HO is considered the predominant ROS produced during XO-mediated oxygen reduction [85]

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However, reduced to oxidized glutathione ratios were not significantly decreased in pancreatic tissue lacking ALDH1L2 owing to a slight increase in reduced glutathione (GSH) levels (Extended Data Fig
