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Our work indicates that non-NE SCLC is exquisitely sensitive to therapeutic induction of ferroptosis whilst NE SCLC demonstrates selective addiction to the TRX redox pathway and plasticity between both subtypes relies on switching between both pathways

CFTR mediates apoptotic volume decrease and cell death by controlling glutathione efflux and ROS production in cultured mice proximal tubules

Blocking this antioxidant axis with SLC7A11 and GPX4 inhibitors (ferroptosis inducers) such as the small-molecule Erastin and RSL3, respectively, leads to uncontrolled accumulation of lipid peroxides at the plasma membrane and other endomembranes within the cell, which promotes membrane permeabilization, damages membrane integrity and ultimately induces ferroptosis [34, 38]

Based on these studies, the process of hair cell regeneration can be categorized into two modes in the basilar papilla: mitotic regeneration and direct transdifferentiation

This highlights TCMs potential as a complementary or alternative therapeutic approach in the multifaceted treatment of breast cancer (Qi et al., 2015