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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

The second group received a single injection of corticosteroid, specifically Triamcinolone acetonide (1 mL, 40 mg), along with anti-inflammatory medications, contrast baths, and shoe insoles as additional therapy

This is undoubtedly an additional concern as ageing is a risk factor for AD and the prevalence of dementia is set to rise as the worldwide population ages [7, 8]

Especially, in contrast with other tissue-specific knockouts of Sod2 , loss of Sod2 in the brain is lethal within 34 wk after birth, suggesting a particularly high sensitivity of neurons to elevated mitochondrial O 2 (Izuo et al., 2015)

Weak, anemic animals eat less, grow slower, and are more susceptible to disease