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Future studies should focus on leveraging single-cell multi-omics technologies to comprehensively characterize the dynamic changes of macrophages within the pulmonary vascular microenvironment, developing cell-specific delivery platforms for precise intervention, and exploring individualized therapeutic strategies based on macrophage phenotyping

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In vitro validation confirmed the inhibitory potential of five of these molecules with a concentration-dependent activity and fibril interaction mediated by the aromatic moieties [348]

[7] Nevertheless, it is prudent for healthcare providers to evaluate each patients context

Although the time-saving effect varied across different strain-antibiotic combinations, this variation primarily reflects the inherent biological differences among pathogen-drug combinations