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Locally acting autocrine/paracrine molecules in the growth plate include Indian hedgehog (Ihh), parathyroid hormone-related protein (PTHrP), fibroblast growth factors (FGFs) (including FGF1, 2, 9 and 18), bone morphogenic proteins (BMPs) (including BMP27), vascular endothelial growth factor (VEGF), IGF-1, and Wnt [2,11,81,85,86,89,90]

However, [Syed and Nordstrom of the Department of Dermatology, University of California-San Francisco, and researchers from three other locations note that] if its incorporation in a gel as a topical agent, in a proper dosage