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The incidence of mammary gland carcinoma in male rats increased in animals treated with 10 mg/kg/day (3 times the MRHD based on AUC)
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Animal studies have shown that 95% hyperoxia substantially enhanced cellular ROS generation, increased apoptosis, induced TRX-1 and TRXR-1 expression while the TRXR-1 activity was reduced
[DOI] [PubMed] [Google Scholar] Li Y, Heng J, Sun D, Zhang B, Zhang X, Zheng Y, Shi WW, Wang TY, Li JY, Sun X, et al
