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Competing interests The authors declare that there are no conflicts of interest

To overcome these troubles, we and two other teams identified the causative gene which was called OCTN2 historically, now known as SLC22A5, around the same time in 1999.3-5 The discovery allows making use of a simple DNA mutation test to make a definitive diagnosis

In a meta-analysis, carnitine reduced serum inflammatory cytokines, including IL-6, TNF- , C-reactive protein (CRP), and MDA, with elevated SOD levels in healthy individuals or patients with specific disorders [146]

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Their effect is dependent on glucose levels