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doi: 10.1016/S2214-109X(13)70113-X
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Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention

[PubMed 1882882] 1648

All study groups modify the intensity of postinduction therapy on the basis of a variety of prognostic factors, including NCI risk group, immunophenotype, early response determinations, and cytogenetics and genomic alterations.[4] Detection of the BCR :: ABL1 fusion (i.e., BCR :: ABL1 -positive ALL) leads to immediate changes in induction therapy, including the addition of a tyrosine kinase inhibitor, such as imatinib or dasatinib.[5] Risk-based treatment assignment requires the availability of prognostic factors that reliably predict outcome
