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W., Jiang F., Chen Y., Yamamoto K

For those with thalassemia, the hematologist will consider a variety of treatment options based on the severity of the symptoms, such as blood transfusions, folic acid supplements, iron chelation, splenectomy, bone marrow transplant, or stem cell transplant, which is the only known curative treatment for thalassemia

Later work has built on that finding, including a 2023 peer-reviewed review on MOTS-Cs role in metabolic disorders

When this enzyme does not work efficiently, either due to environmental and genetic factors, methylation can be impacted

Controls = healthy control subjects) and the compared characteristics are both highlighted in bold
