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This makes B12 supplementation extremely safe, with a low risk of toxicity
Further studies are requisite to confirm their efficacy and safety
Second, it inhibits the synthesis of many pro-inflammatory factors such as tumor necrosis factor- (TNF-), interleukin 1 beta (IL-1), IL-6, interferon-, monocyte chemotactic protein-1, and macrophage inflammatory protein-1 during the inflammatory response [24,25,26] (Figure 2A)
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(19) studied the possible association between MnSOD and GPX1 gene polymorphisms and susceptibility and disease progression of alopecia areata in a Turkish population
