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Factors Supporting a Clean MTHFR To maintain a clean MTHFR, you can focus on supporting it with the following: Vitamin B2 (Riboflavin) Vitamin B6 (Pyridoxine) Vitamin B12 (Methylcobalamin) 7 Folinic Acid (another active form of folate) Eating liver and leafy green vegetables Antioxidants, especially glutathione 4 Healthy thyroid hormone levels 5 Factors Contributing to a Dirty MTHFR Several factors can slow down the function of the MTHFR gene, leading to a dirty MTHFR: Low intake of folate-rich foods such as green leafy vegetables, citrus fruits, and organ meat