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Stage IIID: The tumor is more than 4 millimeters thick, with ulceration

But when they tried to administer it directly, they hit a fundamental problem: -MSH degrades within minutes in the bloodstream, making it impractical as a therapeutic agent

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To test, if MSU crystals may also have the ability to specifically deplete CRP from human body fluids, we incubated different human sera or a BSA solution in HBSS either with zymosan, MSU crystals, or PC-agarose