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Two Primary Biochemical Pathways Undermethylation usually develops through one of two major mechanisms: inadequate production of S-adenosylmethionine (SAM) , the bodys principal methyl donor, or accumulation of S-adenosylhomocysteine (SAH) , which inhibits methyltransferase activity

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2 In both human and mice studies, acute and chronic sleep deprivation resulted in a kind of beta-amyloid (A) plaque accumulation common in Alzheimers disease and dementia

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Wei H, Cai Q, Rahn R (1997) Singlet oxygen involvement in ultraviolet (254 nm) radiation-induced formation of 8-hydroxy-deoxyguanosine in DNA

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