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This cascade leads to neuronal apoptosis and energy deficits, particularly in the prefrontal cortex and hippocampus ( 4.3 Excitotoxicity Synthetic cathinones disrupt glutamatergic signaling by enhancing glutamate release and impairing astrocytic uptake ( 4.4 Neuroinflammation The neurotoxic environment created by synthetic cathinones activates microglia and astrocytes, leading to the release of proinflammatory cytokines, such as IL-1 and TNF-

Importantly, one should remember, that K p,brain and AUC u,brain /AUC u,plasma provide information about the distribution of the parent drug in the whole brain including both intra- and extracellular space compared to plasma, while K p,uu,brain gives knowledge about the distribution of the parent drug between ECF and plasma

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Mit Einverstndnis von Frau Schneider fge ich Auszge aus ihrem sehr interessanten Brief bei, bevor ich darauf eingehe und die komplizierten Mechanismen der Wechselwirkungen erlutere