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Signal Transduct Target Ther 9:319
Notably, we identified VGF (nerve growth factor inducible) as a key regulator of cell hypersecretion, whose expression is controlled by both mTOR-STAT3 and ERK-CREB signaling pathways
Given that FOXO4-DRI remains in the preclinical arena (i.e., animal models, in-vitro cell culture), lets review key studies and what they suggest
The rearrangement of the MYC gene, located on chromosome 8, with the immunoglobulin heavy chain (IGH) or light chain genes results in overexpression of CD38 [9] and downregulation of the LMO2 gene [10]
doi: 10.1152/ajpheart.00291.2008
