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Description
In animal models, intra-articular administration of liraglutide reduced the secretion of inflammatory cytokines such as IL-6, the expression of inflammatory genes in chondrocytes, the amount of proinflammatory M1 macrophages, and improved pain-related behaviors 104
A washout period of at least 1 week separated the 2 arms
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For example, approaches that control M1 polarization could attenuate excessive inflammatory responses and tissue damage
Unfortunately, methadone has failed to change with the times
