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(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)

Significantly higher frequencies of hematinic deficiencies and hyperhomocysteinemia in oral precancer patients

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Hence, its administration should be especially specified in subjects with cardiovascular diseases and/or cardiovascular risk factors