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Opioids such as tramadol and tapentadol are also classified as secondline agents due to risks of developing dependence, respiratory depression, and potential abuse [336, 373]

Inositol, a common type of sugar present in the body, plays a pivotal role in speeding up metabolic processes and reducing blood cholesterol

Metabolomics analysis showed a decrease in NADPH in hypoxic mutant chondrocytes, both during proliferation and differentiation, resulting in a reduced NADPH:NADP + ratio, indicating that hypoxic chondrocytes depend on the PPP for sufficient NADPH production and that other NADPH-generating pathways cannot compensate (Fig

These results confirmed that ROS and the excitatory potency of acidic amino acids such as glutamate are involved in methylmercury-induced neurotoxicity in cerebral neuron cultures