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Figure 4 In general, all immune cells are affected by aging ( In addition, one of the hallmarks of immune senescence is inflammation, which refers to an age-related systemic state of sterile, chronic and low-grade inflammation characterized by the upregulation of blood markers of inflammation and is considered to be a consequence of increasing chronological age, as well as a hallmark of biological senescence, multimorbidity and mortality risk ( In conclusion, the relationships among immune senescence, chronic inflammation and oxidative stress are intertwined and complex

Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E 4: the Hordaland Homocysteine Study