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There are different resistance mechanisms reported in both pre-clinical and clinical studies

Daarnaast reguleren mitochondrin diverse andere processen waaronder celdeling en -differentiatie, apoptose, calciumhomeostase, synthese van nucleotiden en fosfolipiden, aangeboren immuniteit, circadiane ritme en opslag van ijzer (in de vorm van ferritine).(80,103,104,107,111) Het aantal mitochondrin per cel is afhankelijk van de energiebehoefte en is hoog in onder meer het hart, de hersenen, spieren, nieren, alvleesklier en lever

[DOI] [PMC free article] [PubMed] [Google Scholar] Yang H., Chen C., Chen H., Duan X., Li J., Zhou Y., et al

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These include systemic medications such as methotrexate, cyclosporine, retinoids, 6-thioguanine, mycophenolate mofetil, troglitazone, and new biologic agents like adalimumab, alefacept, efalizumab, etanercept, and infliximab, as well as topical therapies like steroids, vitamin D analogues, psoralen, 5-aminolevulinic acid, salicylates, fumaric acid esters, anthralins (dithranol), tacrolimus, and retinoids, such as tazarotene
