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CoQH2/CoQ ratio plays a key role in using the alternative oxidase (AOX) to accept electrons from CoQ and cause a reduction in the CoQH2/CoQ ratio, leading to a decrease in rearranged during transfection (RET) and ROS generation (Szibor et al., 2020)

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310 The discovery that some sirtuins, including mammalian SirT6 311 and Sir2A from Plasmodium falciparum (312) selectively hydrolyze long-chain acyl groups from the side chains of internal lysine residues suggests that this reaction is important enough in vivo for the evolution of protective mechanisms

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