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[DOI] [PubMed] [Google Scholar] Wang Y, Ye J, Ganapathy V, Longo N

Propionyl-L-carnitine is also used to treat congestive heart failure (CHF)

In NAFLD patients, Godex supplementation significantly reduced ALT and AST, increased mtDNA copy number, and decreased oxidative stress marker 8-oxo-7, 8-dihydro2'-deoxyguanosine (8-oxo-dG) ( L-carnitine also ameliorates oxidative stress by reducing ROS production ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) ( Beyond mitochondrial mechanisms, L-carnitine inhibits hepatocyte autophagy and apoptosis

Phase II results Phase II participant characteristics Baseline characteristics for the 16 participants from Phase I who completed Phase II are shown in Table 2