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doi: 10.1126/science.272.5267.1492 138 JeanS.JuneauR

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Curcumin, while poorly absorbed in its native form, undergoes significant metabolic transformation in the liver, resulting in metabolites that are excreted in the urine and contribute to its anti-inflammatory effects

Notably, protein phosphatase 2A (PP2A) and AMP-activated protein kinase (AMPK) modulate the phosphorylation status of Beclin-1 to regulate autophagic flux (Peris et al., 2023)
