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There is no treatment available to cure and effectively reverse the progression of the disease, which may be related to its multi-faceted physiopathological mechanism [5]

As water enters the matrix, it hydrolyses the polymers ester bonds, releasing lactic and glycolic acids

The AKR1C3 encoded enzyme is also known as prostaglandin F synthase

For example, all patients with cirrhosis who are positive for viral surface antigen should be evaluated for antiviral therapy, and patients should be treated with antiviral drugs, with the aim of delaying the progression of cirrhosis and reducing the incidence of liver cancer by inhibiting the replication of the virus (Manolakopoulos et al., 2009)