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According to WHO recommendations, 15%25% of couples have difficulty conceiving

(2006b) evaluated the effects of local administration of VEGF165 on the semitendinosus tendon graft after ACL reconstruction and found that VEGF165 increased sheep knee laxity and decreased the stiffness of the grafted tendon 12 weeks after ACL reconstruction

Long-term safety in injectable use is not well characterized in published trials

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