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Among the theories that explain the aging process, the free radical theory of aging is long-established (Harman, 1956)

Helped with tendon pain and overall joint comfort

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J Clin Invest 2001;106:1095103

Such Sirts have the potential to downregulate the NF-B pathway, which helps reduce neuroinflammation (Paxinou et al., 2001) Sirt2 has been reported to deacetylate NOD-like receptor pyrin domain containing 3 (NLRP3) and prevent aging-related chronic inflammation (Qin et al., 2017)
