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Potent and specific MTH1 inhibitors targeting gastric cancer

Ethics declarations The author declares no conflicts of interest

Why cysteine is the rate-limiting factor: The intracellular concentration of cysteine sits close to the Km value of GCL (0.1 to 0.3 mM), meaning the enzyme is operating near its saturation point under normal conditions

We do not know whether the effects are truly additive, partially redundant, or potentially counterproductive in some way

Neutrophils are the first responders to infection or injury, playing a key role in the inflammatory response, while lymphocytes are responsible for adaptive immunity, including the recognition of pathogens and immune memory