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Moreover, the IN codelivery of berberine and evodiamine by selfassembled thermosensitive hydrogels, showed good release properties and achieved antidepressant effects by regulating monoamine neurotransmitter metabolism and related metabolic pathways, providing a noninvasive treatment strategy for the clinical treatment of depression [407]

[Google Scholar] Pdi-regulated disulfide bond formation in protein folding and biomolecular assembly

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