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1 Introduction Mitochondria are organelles in almost all eukaryotic cells, performing essential functions such as ATP production, calcium signaling, lipid biogenesis, oxidative stress regulation, and apoptosis

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Histone deacetylases (HDAC), common in mammals [33, 50], are de-lactylation enzymes that effectively remove Kl-la and Kd-la modifications

It acts primarily as an intestinal binder, preventing reabsorption of metals excreted in bile