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Sep 24 2020;15(7):725-732

Table 1)

The specific vulnerability of the gastrointestinal system to TD, in the absence of more common signs of wet and dry beriberi, may arise from direct exposure of this system to the gut microbiome and oral drugs, along with the continuous need to redistribute thiamine to other tissues

In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation