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Exercise therapy, particularly resistance training, derives part of its benefits from regulating chronic inflammation and oxidative stress
Attesting to such a role, specific deletion of the perivascular pool of AQP4 significantly reduces the size of experimentally induced edema 565 , mimicking the effect of a global AQP4 knockout 566

Knockouts suffer from lethal paralysis in newborns, which is due to an abolished evoked release of presynaptic vesicles at neuromuscular junctions whereas endplate morphology appears intact 29
Immune cells, including T cells, tumor-associated macrophages, myeloid-derived suppressor cells, dendritic cells (DCs), B cells and natural killer cells, collectively form the TIME (71)
Dermatol 24 (4), e70181